A new benzophenanthridine alkaloid from caloncoba glauca

Jabar B.P.A.A. Agbo; James D.S. Mpetga; Raphael Bikanga; Roland T. Tchuenguem; Rolande B.N. Tsafack; Maurice D. Awouafack; Jean P. Dzoyem; Takuya Ito; Hiroyuki Morita; Pierre Tane

doi:10.1177/1934578x1701200314

A new benzophenanthridine alkaloid from caloncoba glauca

Jabar B.P.A.A. Agbo, James D.S. Mpetga, Raphael Bikanga, Roland T. Tchuenguem, Rolande B.N. Tsafack, Maurice D. Awouafack, Jean P. Dzoyem, Takuya Ito, Hiroyuki Morita, Pierre Tane^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 μg/mL (C. krusei)] had moderate to weak antifungal activity.

Original language	English
Pages (from-to)	367-368
Number of pages	2
Journal	Natural Product Communications
Volume	12
Issue number	3
DOIs	https://doi.org/10.1177/1934578x1701200314
State	Published - 2017/03

Keywords

Antimicrobial
Benzophenanthridine alkaloid
Caloncoba glauca
Flacourtiaceae
N-formyldihydrochelerythrine

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1701200314

Cite this

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title = "A new benzophenanthridine alkaloid from caloncoba glauca",

abstract = "Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 μg/mL (C. krusei)] had moderate to weak antifungal activity.",

keywords = "Antimicrobial, Benzophenanthridine alkaloid, Caloncoba glauca, Flacourtiaceae, N-formyldihydrochelerythrine",

author = "Agbo, {Jabar B.P.A.A.} and Mpetga, {James D.S.} and Raphael Bikanga and Tchuenguem, {Roland T.} and Tsafack, {Rolande B.N.} and Awouafack, {Maurice D.} and Dzoyem, {Jean P.} and Takuya Ito and Hiroyuki Morita and Pierre Tane",

year = "2017",

month = mar,

doi = "10.1177/1934578x1701200314",

language = "英語",

volume = "12",

pages = "367--368",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "3",

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TY - JOUR

T1 - A new benzophenanthridine alkaloid from caloncoba glauca

AU - Agbo, Jabar B.P.A.A.

AU - Mpetga, James D.S.

AU - Bikanga, Raphael

AU - Tchuenguem, Roland T.

AU - Tsafack, Rolande B.N.

AU - Awouafack, Maurice D.

AU - Dzoyem, Jean P.

AU - Ito, Takuya

AU - Morita, Hiroyuki

AU - Tane, Pierre

PY - 2017/3

Y1 - 2017/3

N2 - Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 μg/mL (C. krusei)] had moderate to weak antifungal activity.

AB - Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 μg/mL (C. krusei)] had moderate to weak antifungal activity.

KW - Antimicrobial

KW - Benzophenanthridine alkaloid

KW - Caloncoba glauca

KW - Flacourtiaceae

KW - N-formyldihydrochelerythrine

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U2 - 10.1177/1934578x1701200314

DO - 10.1177/1934578x1701200314

M3 - 学術論文

AN - SCOPUS:85019096572

SN - 1934-578X

VL - 12

SP - 367

EP - 368

JO - Natural Product Communications

JF - Natural Product Communications

IS - 3

ER -

A new benzophenanthridine alkaloid from caloncoba glauca

Abstract

Keywords

ASJC Scopus subject areas

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