A DNA duplex-based, tailor-made fluorescent sensor for porphyrin derivatives

Kazuhisa Fujimoto; Yu Muto; Masahiko Inouye

doi:10.1021/bc800133e

A DNA duplex-based, tailor-made fluorescent sensor for porphyrin derivatives

Kazuhisa Fujimoto^*, Yu Muto, Masahiko Inouye

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Abstract

We synthesized a DNA-based fluorescent sensor, tailored to the recognition and signaling for hydrophobic guest molecules. The sensor molecule is made of three functional moieties, per-O-methylated β-cyclodextrin (per-Me-β-CD), DNA, and pyrene as guest-binding, dimerizing, and signaling ones, respectively. Addition of a porphyrin derivative as a hydrophobic guest molecule induced emission switching of the sensor molecule from monomer to excimer due to the DNA hybridization promoted by the host-guest binding.

Original language	English
Pages (from-to)	1132-1134
Number of pages	3
Journal	Bioconjugate Chemistry
Volume	19
Issue number	6
DOIs	https://doi.org/10.1021/bc800133e
State	Published - 2008/06

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

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abstract = "We synthesized a DNA-based fluorescent sensor, tailored to the recognition and signaling for hydrophobic guest molecules. The sensor molecule is made of three functional moieties, per-O-methylated β-cyclodextrin (per-Me-β-CD), DNA, and pyrene as guest-binding, dimerizing, and signaling ones, respectively. Addition of a porphyrin derivative as a hydrophobic guest molecule induced emission switching of the sensor molecule from monomer to excimer due to the DNA hybridization promoted by the host-guest binding.",

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AB - We synthesized a DNA-based fluorescent sensor, tailored to the recognition and signaling for hydrophobic guest molecules. The sensor molecule is made of three functional moieties, per-O-methylated β-cyclodextrin (per-Me-β-CD), DNA, and pyrene as guest-binding, dimerizing, and signaling ones, respectively. Addition of a porphyrin derivative as a hydrophobic guest molecule induced emission switching of the sensor molecule from monomer to excimer due to the DNA hybridization promoted by the host-guest binding.

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A DNA duplex-based, tailor-made fluorescent sensor for porphyrin derivatives

Abstract

ASJC Scopus subject areas

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