A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis

Yutaka Kawano; Shohei Kikuchi; Koji Miyanishi; Hiroyuki Nagashima; Masahiro Hirakawa; Fumito Tamura; Makoto Yoshida; Sho Takahashi; Kohichi Takada; Tsuyoshi Hayashi; Tsutomu Sato; Yasushi Sato; Risyu Takimoto; Masayoshi Kobune; Masaki Kawamoto; Toru Mizuguchi; Koichi Hirata; Tadashi Hasegawa; Junji Kato

doi:10.2957/kanzo.53.615

A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis

Yutaka Kawano^*, Shohei Kikuchi, Koji Miyanishi, Hiroyuki Nagashima, Masahiro Hirakawa, Fumito Tamura, Makoto Yoshida, Sho Takahashi, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Yasushi Sato, Risyu Takimoto, Masayoshi Kobune, Masaki Kawamoto, Toru Mizuguchi, Koichi Hirata, Tadashi Hasegawa, Junji Kato

^*Corresponding author for this work

Hematology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report rare case of double cholangiolocellular carcinoma (CLC) and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis (NASH). A 68-years old female with NASH was admitted to the hospital for examination and treatment of multiple hepatic tumors. Gd-EOB-DTPA enhanced MRI showed that tumor was located in segment 3, segment 4, and segment 6. The angiography and CT during angiography showed additional three tumors in segment 1 and segment 6. These tumors might be different tumor origin because of different imaging pattern. Operation was performed in segment 3 and 4, and RFA was performed in segment 1 and 6 because these tumors were diagnosed as hepatocellular carcinoma. Whitish tumor with clear margin which has no fibrous capsule was seen in tumor in segment 3. Pathologically, tumor in segment 3 showed CLC. Tumor in segment 4 was diagnosed as dysplastic nodule.

Original language	English
Pages (from-to)	615-623
Number of pages	9
Journal	Acta Hepatologica Japonica
Volume	53
Issue number	10
DOIs	https://doi.org/10.2957/kanzo.53.615
State	Published - 2012

Keywords

Cholangiolocellular carcinoma
Hepatic progenitor cells
Hepatocellular carcinoma
Immunostaining
Non-alcoholic steatohepatitis

ASJC Scopus subject areas

Hepatology

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10.2957/kanzo.53.615

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Kawano, Y., Kikuchi, S., Miyanishi, K., Nagashima, H., Hirakawa, M., Tamura, F., Yoshida, M., Takahashi, S., Takada, K., Hayashi, T., Sato, T., Sato, Y., Takimoto, R., Kobune, M., Kawamoto, M., Mizuguchi, T., Hirata, K., Hasegawa, T., & Kato, J. (2012). A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis. Acta Hepatologica Japonica, 53(10), 615-623. https://doi.org/10.2957/kanzo.53.615

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title = "A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis",

abstract = "We report rare case of double cholangiolocellular carcinoma (CLC) and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis (NASH). A 68-years old female with NASH was admitted to the hospital for examination and treatment of multiple hepatic tumors. Gd-EOB-DTPA enhanced MRI showed that tumor was located in segment 3, segment 4, and segment 6. The angiography and CT during angiography showed additional three tumors in segment 1 and segment 6. These tumors might be different tumor origin because of different imaging pattern. Operation was performed in segment 3 and 4, and RFA was performed in segment 1 and 6 because these tumors were diagnosed as hepatocellular carcinoma. Whitish tumor with clear margin which has no fibrous capsule was seen in tumor in segment 3. Pathologically, tumor in segment 3 showed CLC. Tumor in segment 4 was diagnosed as dysplastic nodule.",

keywords = "Cholangiolocellular carcinoma, Hepatic progenitor cells, Hepatocellular carcinoma, Immunostaining, Non-alcoholic steatohepatitis",

author = "Yutaka Kawano and Shohei Kikuchi and Koji Miyanishi and Hiroyuki Nagashima and Masahiro Hirakawa and Fumito Tamura and Makoto Yoshida and Sho Takahashi and Kohichi Takada and Tsuyoshi Hayashi and Tsutomu Sato and Yasushi Sato and Risyu Takimoto and Masayoshi Kobune and Masaki Kawamoto and Toru Mizuguchi and Koichi Hirata and Tadashi Hasegawa and Junji Kato",

year = "2012",

doi = "10.2957/kanzo.53.615",

language = "英語",

volume = "53",

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Kawano, Y, Kikuchi, S, Miyanishi, K, Nagashima, H, Hirakawa, M, Tamura, F, Yoshida, M, Takahashi, S, Takada, K, Hayashi, T, Sato, T, Sato, Y, Takimoto, R, Kobune, M, Kawamoto, M, Mizuguchi, T, Hirata, K, Hasegawa, T & Kato, J 2012, 'A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis', Acta Hepatologica Japonica, vol. 53, no. 10, pp. 615-623. https://doi.org/10.2957/kanzo.53.615

TY - JOUR

T1 - A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis

AU - Kawano, Yutaka

AU - Kikuchi, Shohei

AU - Miyanishi, Koji

AU - Nagashima, Hiroyuki

AU - Hirakawa, Masahiro

AU - Tamura, Fumito

AU - Yoshida, Makoto

AU - Takahashi, Sho

AU - Takada, Kohichi

AU - Hayashi, Tsuyoshi

AU - Sato, Tsutomu

AU - Sato, Yasushi

AU - Takimoto, Risyu

AU - Kobune, Masayoshi

AU - Kawamoto, Masaki

AU - Mizuguchi, Toru

AU - Hirata, Koichi

AU - Hasegawa, Tadashi

AU - Kato, Junji

PY - 2012

Y1 - 2012

N2 - We report rare case of double cholangiolocellular carcinoma (CLC) and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis (NASH). A 68-years old female with NASH was admitted to the hospital for examination and treatment of multiple hepatic tumors. Gd-EOB-DTPA enhanced MRI showed that tumor was located in segment 3, segment 4, and segment 6. The angiography and CT during angiography showed additional three tumors in segment 1 and segment 6. These tumors might be different tumor origin because of different imaging pattern. Operation was performed in segment 3 and 4, and RFA was performed in segment 1 and 6 because these tumors were diagnosed as hepatocellular carcinoma. Whitish tumor with clear margin which has no fibrous capsule was seen in tumor in segment 3. Pathologically, tumor in segment 3 showed CLC. Tumor in segment 4 was diagnosed as dysplastic nodule.

AB - We report rare case of double cholangiolocellular carcinoma (CLC) and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis (NASH). A 68-years old female with NASH was admitted to the hospital for examination and treatment of multiple hepatic tumors. Gd-EOB-DTPA enhanced MRI showed that tumor was located in segment 3, segment 4, and segment 6. The angiography and CT during angiography showed additional three tumors in segment 1 and segment 6. These tumors might be different tumor origin because of different imaging pattern. Operation was performed in segment 3 and 4, and RFA was performed in segment 1 and 6 because these tumors were diagnosed as hepatocellular carcinoma. Whitish tumor with clear margin which has no fibrous capsule was seen in tumor in segment 3. Pathologically, tumor in segment 3 showed CLC. Tumor in segment 4 was diagnosed as dysplastic nodule.

KW - Cholangiolocellular carcinoma

KW - Hepatic progenitor cells

KW - Hepatocellular carcinoma

KW - Immunostaining

KW - Non-alcoholic steatohepatitis

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U2 - 10.2957/kanzo.53.615

DO - 10.2957/kanzo.53.615

M3 - 学術論文

AN - SCOPUS:85051666105

SN - 0451-4203

VL - 53

SP - 615

EP - 623

JO - Acta Hepatologica Japonica

JF - Acta Hepatologica Japonica

IS - 10

ER -

A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis

Abstract

Keywords

ASJC Scopus subject areas

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