[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

Takenori Tomohiro; Akito Yamamoto; Yoko Tatsumi; Yasumaru Hatanaka

doi:10.1039/c3cc45780j

[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

Takenori Tomohiro^*, Akito Yamamoto, Yoko Tatsumi, Yasumaru Hatanaka

^*Corresponding author for this work

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A coumarin-fused diazirine photolabeling agent exhibited dramatic enhancement in fluorescence after cross-linking with the target protein. Fluorescence emission from the coumarin moiety was efficiently quenched by the diazirine group, and was then intensively recovered from photolysis treatment by irradiation with light at a wavelength of 365 nm.

Original language	English
Pages (from-to)	11551-11553
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	98
DOIs	https://doi.org/10.1039/c3cc45780j
State	Published - 2013/11/14

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc45780j

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title = "[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon",

abstract = "A coumarin-fused diazirine photolabeling agent exhibited dramatic enhancement in fluorescence after cross-linking with the target protein. Fluorescence emission from the coumarin moiety was efficiently quenched by the diazirine group, and was then intensively recovered from photolysis treatment by irradiation with light at a wavelength of 365 nm.",

author = "Takenori Tomohiro and Akito Yamamoto and Yoko Tatsumi and Yasumaru Hatanaka",

year = "2013",

month = nov,

day = "14",

doi = "10.1039/c3cc45780j",

language = "英語",

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journal = "Chemical Communications",

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T1 - [3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

AU - Tomohiro, Takenori

AU - Yamamoto, Akito

AU - Tatsumi, Yoko

AU - Hatanaka, Yasumaru

PY - 2013/11/14

Y1 - 2013/11/14

N2 - A coumarin-fused diazirine photolabeling agent exhibited dramatic enhancement in fluorescence after cross-linking with the target protein. Fluorescence emission from the coumarin moiety was efficiently quenched by the diazirine group, and was then intensively recovered from photolysis treatment by irradiation with light at a wavelength of 365 nm.

AB - A coumarin-fused diazirine photolabeling agent exhibited dramatic enhancement in fluorescence after cross-linking with the target protein. Fluorescence emission from the coumarin moiety was efficiently quenched by the diazirine group, and was then intensively recovered from photolysis treatment by irradiation with light at a wavelength of 365 nm.

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U2 - 10.1039/c3cc45780j

DO - 10.1039/c3cc45780j

M3 - 学術論文

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AN - SCOPUS:84887871484

SN - 1359-7345

VL - 49

SP - 11551

EP - 11553

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon

Abstract

ASJC Scopus subject areas

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