Electrophysiological analysis of colonic ion secretion mechanism by TRP channels

Since spices such as wasabi are used as stomach medicines in Oriental medicine, they are suggested to regulate colonic functions. In the present study, we investigated the mechanism that aryl isothiocyanates （AITC), which are a main pungent component of wasabi, triggers Clsecretion in colonic mucosa isolated from mice and rats. As a result, we demonstrated that AITC caused Clsecretion via PGE2 production in colonic mucosa and that TRPA1 channel may not be a key molecule in the AITC-induced Clsecretion in the colon. This study proposes a novel mechanism of AITC action in the colon