Project Details
Description
Cumulus cells have been suggested to promote fertilization although the precise mechanism remains unclear. We showed that PACAP was present in the mouse sperm acrosome and it stimulated cumulus cells to secrete fertilization-promoting factorswhich accelerate sperm penetration through the zona pellucida. We identified neurokinin A as a cumulus cell factor that enhanced both the sperm motility and acrosome reactionwhich are necessary for sperm to penetrate the zona pellucida.
| Status | Finished |
|---|---|
| Effective start/end date | 2010/01/01 → 2012/01/01 |
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