Research output per year
Research output per year
Project Details
Outline of Final Research Achievements
It is revealed that ABCD1 possesses acyl-CoA thioesterase activity and its activity is essential for the transport of acyl-CoA into peroxisome. In addition, it is revealed that ABCD4 makes complex with lysosomal protein LMBD1 on endoplasmic reticulum membranes and translocates from ER to lysosome dependent on lysosomal targeting signal of LMBD1. Furthermore, we succeeded to prepare proteoliposome of ABCD1-4. It becomes possible to characterized precise mechanism of substrate transport by ABCD1-4.
| Status | Finished |
|---|---|
| Effective start/end date | 2014/04/01 → 2017/03/31 |
Funding
- Japan Society for the Promotion of Science: ¥5,070,000.00
Keywords
- ABCトランスポーター
- ペルオキシソーム
- リソソーム
- オルガネラ局在化機構
- 獄長鎖脂肪酸CoA輸送
- ビタミンB12輸送
- 副腎白質ジストロフィー
- ビタミンB12欠乏症
- 極長鎖脂肪酸CoA輸送
Research output
- 4 Article
-
A novel method for determining peroxisomal fatty acid β-oxidation
Morita, M., Matsumoto, S., Okazaki, A., Tomita, K., Watanabe, S., Kawaguchi, K., Minato, D., Matsuya, Y., Shimozawa, N. & Imanaka, T., 2016/09/01, In: Journal of Inherited Metabolic Disease. 39, 5, p. 725-731 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
Kawaguchi, K., Okamoto, T., Morita, M. & Imanaka, T., 2016/07/26, In: Scientific Reports. 6, 30183.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase
Morita, M., Kawamichi, M., Shimura, Y., Kawaguchi, K., Watanabe, S. & Imanaka, T., 2015/12/01, In: Metabolic Brain Disease. 30, 6, p. 1359-1367 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations