Clarification of molecular mechanism of bacterial divisome formation

  • Matsui, Takashi (Principal Investigator)

Project Details

Outline of Final Research Achievements

Subsequently, to determine the complex structure of FtsZ with FtsA, the conditions of FtsA under complex state were measured. Crystal structure of FtsA apo form suggested that FtsA seemed to have ATPase activity. ATPase activity of FtsA with or without FtsZ was not detected. However, polymerized FtsZ or monomeric FtsZ’s mutant bound to FtsA with 1:2 ratio of FtsA: FtsZ. It was seemed that ATPase activity might be not correlated with interaction of FtsZ.
StatusFinished
Effective start/end date2012/04/012015/03/31

Funding

  • Japan Society for the Promotion of Science: ¥4,550,000.00

Keywords

  • FtsZ
  • FtsA
  • 細菌の細胞分裂
  • Divisome
  • 構造解析
  • X線結晶構造解析
  • 真正細菌
  • 細胞分裂
  • 真性細菌
  • タンパク質複合体