Research output per year
Research output per year
Project Details
Abstract
The present findings have established the new concept that specific subtypes of hemichannels, i.e., pannexin 1 and connexin 43, at the human blood-brain barrier (BBB) make a significant contribution to the dysfunction of the BBB transport system under acute ischemic conditions. This could raise the potential of the BBB hemichannels as a therapeutic target for brain ischemic damage exaggeration.
| Status | Finished |
|---|---|
| Effective start/end date | 2010/04/01 → 2014/03/31 |
Funding
- Japan Society for the Promotion of Science: ¥25,350,000.00
Keywords
- ヘミチャネル
- 脳毛細血管内皮細胞
- パネキシン
- コネキシン
- 輸送
- 血液脳関門
- 病態
- 阻害
- トランスポーター
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A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: Role of the blood-cerebrospinal barrier transporters
Tachikawa, M., Tsuji, K., Yokoyama, R., Higuchi, T., Ozeki, G., Yashiki, A., Akanuma, S. I., Hayashi, K., Nishiura, A. & Hosoya, K. I., 2012/12, In: Journal of Pharmacology and Experimental Therapeutics. 343, 3, p. 608-616 9 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain
Tachikawa, M., Ozeki, G., Higuchi, T., Akanuma, S. I., Tsuji, K. & Hosoya, K. I., 2012/12, In: Journal of Neurochemistry. 123, 5, p. 750-760 11 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier
Fujiyoshi, M., Tachikawa, M., Ohtsuki, S., Ito, S., Uchida, Y., Akanuma, S. I., Kamiie, J., Hashimoto, T., Hosoya, K. I., Iwatsubo, T. & Terasaki, T., 2011/08, In: Journal of Neurochemistry. 118, 3, p. 407-415 9 p.Research output: Contribution to journal › Article › peer-review