Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mouse

  • 佐久間勉 (Principal Investigator)
  • 根本信雄 (Co-Investigator(Kenkyū-buntansha))
  • 河崎, 優希 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

To clarify the molecular mechanisms of female-dominant expression of drug-metabolizing enzyme CYP3As in the liver, we analyzed the mechanisms of female-specific expression of mouse Cyp3a41 gene. Our results indicated that HNF4α plays an important role in the transcriptional activation of the Cyp3a41 gene, and a sex difference in chromatin structure may contribute to the female-specific expression of Cyp3a41 in the livers of mice.
StatusFinished
Effective start/end date2008/01/012010/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,810,000.00

Keywords

  • 薬物代謝酵素
  • CYP3A
  • 発現制御
  • 性差
  • マウス
  • シトクロムP450
  • 性特異性