Research output per year
Research output per year
Project Details
Abstract
To clarify the molecular mechanisms of female-dominant expression of drug-metabolizing enzyme CYP3As in the liver, we analyzed the mechanisms of female-specific expression of mouse Cyp3a41 gene. Our results indicated that HNF4α plays an important role in the transcriptional activation of the Cyp3a41 gene, and a sex difference in chromatin structure may contribute to the female-specific expression of Cyp3a41 in the livers of mice.
| Status | Finished |
|---|---|
| Effective start/end date | 2008/01/01 → 2010/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,810,000.00
Keywords
- 薬物代謝酵素
- CYP3A
- 発現制御
- 性差
- マウス
- シトクロムP450
- 性特異性
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Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes
S., K., W., C., A., J., T., S. & N., N., 2011, In: Toxicology 280. p. 18-23Research output: Contribution to journal › Article › peer-review
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Hepatocyte nuclear factor 4 alpha regulates expression of the mouse female-specific Cyp3a41 gene in the liver
W., B., T., S., Y., K. & N, N., 2011, In: Drug Metabolism and Disposition. 39, 3, p. 490-497Research output: Contribution to journal › Article › peer-review
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Cyp3a41遺伝子メス特異的発現の調節機構
佐久間勉, Wattanaporn, B., 河崎優希, 近藤佐千子 & 根本信雄, 2010.Research output: Contribution to conference › Presentation