Research output per year
Research output per year
Project Details
Abstract
The mechanisms underlying the pharmacological effects of kakkonto in murine food allergy model were examined. As a result, kakkonto facilitated the differentiation from naive helper T cells to CD25 negative CD3+CD4+FR4+Foxp3+T cells in the immunological responses within the mucosal immune system of the intestine and thereby alleviated the allergic responses. However, the further detailed investigation of the underlying mechanisms is needed.
| Status | Finished |
|---|---|
| Effective start/end date | 2009/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,420,000.00
Keywords
- 東洋医学
- 腸管粘膜免疫系
- 葛根湯
- 食物アレルギー
- 制御性T細胞
- 活性化T細胞
- 末梢性免疫寛容
- 樹状細胞
- Foxp3
- CD25
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Oral tolerance induced by transfer of food antigens via breast milk of allergic mothers prevents offspring from developing allergic symptoms in a mouse food allergy model
Yamamoto, T., Tsubota, Y., Kodama, T., Kageyama-Yahara, N. & Kadowaki, M., 2012, In: Clinical and Developmental Immunology. 2012, 721085.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Rab5a regulates surface expression of FcεRI and functional activation in mast cells
Kageyama-Yahara, N., Suehiro, Y., Yamamoto, T. & Kadowaki, M., 2011/05, In: Biological and Pharmaceutical Bulletin. 34, 5, p. 760-763 4 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells
Kageyama-Yahara, N., Wang, X., Katagiri, T., Wang, P., Yamamoto, T., Tominaga, M. & Kadowaki, M., 2011/12/16, In: Biochemical and Biophysical Research Communications. 416, 3-4, p. 283-288 6 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations