Establishment of the treatment and pathophysiology based on the susceptibility gene in lumbar disc disease.

Safranin O staining in intervertebral disc were significantly decreased in Nucleus pulposus tissues of Tg mice compared to controls. MRI analysis indicated obvious progression of degenerative intervertebral discs in Tg mice, which suggested reduction of the intensity of lumbar T2 weighted MR imaging. The cervical intervertebral disc degeneration and hernia models were established by introducing instability into cervical vertebrate of CILP Tg mice. The histological analysis suggested that progression of intervertebral disc degeneration and regulation of TGF-βsignaling. There may be a possibility that CILP enhance intervertebral disc degeneration.