Clinical and basic study on social brain

  • 倉知, 正佳 (Principal Investigator)
  • 鈴木, 道雄 (Co-Investigator(Kenkyū-buntansha))
  • 川崎, 康弘 (Co-Investigator(Kenkyū-buntansha))
  • 住吉, 太幹 (Co-Investigator(Kenkyū-buntansha))
  • 上原, 隆 (Co-Investigator(Kenkyū-buntansha))
  • 高橋, 努 (Co-Investigator(Kenkyū-buntansha))
  • 角田, 雅彦 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

4) Rodents treated with N-Methyl-D-aspartate (NMDA) antagonists have been thought to be an animal model of schizophrenia. In this study, we examined gene expression in the amygdala of rats chronically treated with MK-801, as well as behavioral changes, such as social behavior, in these animals. Changed in mRNA levels were analyzed using a GeneChip microaaray system in male Wistar rats injected with MX-801 (0.13 mg/kg i.p.) or saline for 14 days. We found 23 downregulated genes and 16 upregulated genes, with the gene encoding arginine-vasopressin being most down regulated, quantified by RT-qPCR assay (Matsuoka, et. Al., 2008).
StatusFinished
Effective start/end date2005/01/01 → 2007/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,870,000.00

Keywords

  • シュナイダー一級症状
  • 海馬傍回
  • 脳由来神経栄養因子
  • ヘッシェル横回
  • MK-801
  • アルギニンバソプレッシン
  • 扁桃体
  • 磁気共鳴画像
  • 社会脳
  • 統合失調症
  • 幻聴
  • 脳画像
  • 遺伝子発現
  • Schneider's symptoms
  • Parahippocampal gyrus
  • Brain derived neurotrophic factor
  • Heschl's gyrus
  • Arginine-vasopressin
  • Amygdala
  • Magnetic resonance imaging

Access Project

View all 4 Research outputs