Novel pathophysiological mechanisms involving the aberrant trafficking of sodium pump in human cancer cells

  • 藤井, 拓人 (Principal Investigator)

Project Details

Abstract

Na+, K+-ATPaseα3-isoform(α3NaK) is abnormally expressed in various types of human cancer cells.α3NaK is not localized in plasma membrane, but in intracellular vesicles in which rab10 is present. In vitro and in vivo studies using human and mouse cancer cells showed thatα3NaK may be involved in the mechanisms of cancer cell survival and growth.
StatusFinished
Effective start/end date2010/01/012011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,900,000.00

Keywords

  • ナトリウムポンプ
  • トラフィッキング
  • 原形質膜
  • 小胞
  • 癌細胞
  • Na^+,K^+-ATPase α3-isoform
  • 小胞体
  • 分泌小胞