Investigation of the mechanism by which novel phosphorylated RNA polymerase II-interacting factors coordinate processes required for gene expression

  • 広瀬, 豊 (Principal Investigator)

Project Details

Abstract

RNA polymerase II (Pol II) copies genetic information from DNA to RNA. The carboxy-terminal domain (CTD) of Pol II is subjected to reversible phosphorylation during transcription cycle and plays an important role in gene expression. Recently, I identified a novel human protein PCIF1 as a phosphorylated CTD-interacting protein. In this study, I investigated PCIF1's function in gene expression. My data suggests that PCIF1 binds Pol II at promoter region during early phase of transcription cycle and modulates phosphorylation level of the CTD.
StatusFinished
Effective start/end date2008/01/012010/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,680,000.00

Keywords

  • 遺伝子発現調節
  • 転写
  • RNAポリメラーゼII
  • リン酸化
  • WWドメイン
  • 遺伝子発現
  • RNAプロセシン
  • PCIF1
  • Pin1
  • RNAプロセシング
  • 遺伝情報発現調節