Analysis of a novel prepro-BDNF expression and function

  • Fukuchi, Mamoru (Principal Investigator)

Project Details

Abstract

In this study, I investigated the mechanism of mRNA expression of brain-derived neurotrophic factor (BDNF), which is involved in expressing a variety of neuronal functions. I found that RNA splicing of BDNF exon I-IX, which is one of alternative BDNF transcripts, was enhanced by Ca2+-CaMK signal evoked by neuronal activity. Moreover, a novel prepro-BDNF protein was generated from BDNF exon I-IX mRNA. These results provide a novel insight into BDNF expression in neurons
StatusFinished
Effective start/end date2011/01/012012/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,290,000.00

Keywords

  • BDNF
  • スプライシング
  • 神経活動
  • BDNF前駆体