Research output per year
Research output per year
Project Details
Abstract
Approximately 15-20% of patients with X-linked agammaglobulinemia(XLA), which is caused by BTK deficiency, have neutropenia, and it is associated with the severity of infection. BTK-deficient neutrophils had more production of reactive oxygen species(ROS) after various stimuli, which was associated with more apoptosis. The production of ROS and apoptosis of BTK-deficient neutrophils were reversed by transduction of recombinant BTK. These data suggest that severe neutropenia in patients with XLA can be treated with recombinant BTK.
| Status | Finished |
|---|---|
| Effective start/end date | 2009/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,420,000.00
Keywords
- 抗体産生不全症
- 自然免疫
- X連鎖無ガンマグロブリン血症
- Toll様受容体
- ブルトンチロシンキナーゼ
Research output
- 5 Article
-
Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis
Nakaoka, H., Kanegane, H., Taneichi, H., Miya, K., Yang, X., Nomura, K., Takezaki, S., Yamada, M., Ohara, O., Kamae, C., Imai, K., Nonoyama, S., Wada, T., Yachie, A., Hershfield, M. S., Ariga, T. & Miyawaki, T., 2012/06, In: International Journal of Hematology. 95, 6, p. 692-696 5 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection
Nomura, K., Kanegane, H., Otsubo, K., Wakiguchi, H., Noda, Y., Kasahara, Y. & Miyawaki, T., 2011/06, In: International Journal of Hematology. 93, 6, p. 760-764 5 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Disseminated BCG infection mimicking metastatic nasopharyngeal carcinoma in an immunodeficient child with a novel hypomorphic NEMO mutation
Imamura, M., Kawai, T., Okada, S., Izawa, K., Takachi, T., Iwabuchi, H., Yoshida, S., Hosokai, R., Kanegane, H., Yamamoto, T., Umezu, H., Nishikomori, R., Heike, T., Uchiyama, M. & Imai, C., 2011/10, In: Journal of Clinical Immunology. 31, 5, p. 802-810 9 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations