Research output per year
Research output per year
Project Details
Abstract
This study was intended to elucidate the functional maturation process of human regulatory T (Treg) cells through the pathogenic examination of congenital deficiency of Treg cells (IPEX). We developed the simple and easy method by flow cytometry for detection of IPEX patients, resulting in identification of some new IPEX cases in Japan. Based on the analyses of IPEX patients, the IPEX case undergoing bone marrow transplantation, carriers, newborns and healthy adults, it could partially be clarified that FOXP3, the product of the gene responsible for IPEX, plays a crucial role in development and differentiation of Treg cells in humans.
| Status | Finished |
|---|---|
| Effective start/end date | 2008/01/01 → 2010/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥18,330,000.00
Keywords
- 制御性T細胞
- FOXP3遺伝子
- IPEX
- フローサイトメトリー
- 遺伝子解析
- IL-7受容体
- FOXP3
- CD4^+CD25^+T細胞
- アトピー性皮膚炎
- IL-7R(CD127)
- CD4^+CD25^+CD127^<dim>T細胞
- フローサイトメトー
- IL-7R (CD127)
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Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry.
M, Z., H, K. & al., E., 2011, In: Cytometry B Clin Cytom. 80, p. 8-13Research output: Contribution to journal › Article › peer-review
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Effect of the VKORC1 genotype on warfarin dose requirements in Japanese pediatric patients
Kato, Y., Ichida, F., Saito, K., Watanabe, K., Hirono, K., Miyawaki, T., Yoshimura, N., Horiuchi, I., Taguchi, M. & Hashimoto, Y., 2011, In: Drug Metabolism and Pharmacokinetics. 26, 3, p. 295-299 5 p.Research output: Contribution to journal › Comment/debate
40 Scopus citations -
Noncompaction study collaborators.Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death.
B, C., K, H., H, T., F, I., T, M. & al., E., 2011, In: Mol Genet Metab. 100(2). 102, p. 200-206Research output: Contribution to journal › Article › peer-review