Research output per year
Research output per year
Project Details
Abstract
Soluble endoglin, which antagonizes vascularization, is elevated in serum in preeclamptic women. This study showed soluble endoglin inhibited hypoxia-induced autophagy in extravillous trophoblasts. Additionally, p62 protein, which is a selective protein degraded by autophagosome, accumulated in extravillous trophoblasts in placental bed biopsy samples of preeclampsia as well as autophagy-deficient EVT cell lines. Taken together, soluble endoglin-mediated autophagy inhibition in extravillous trophoblast was involved in pathophysiology of preeclampsia.
| Status | Finished |
|---|---|
| Effective start/end date | 2011/01/01 → 2012/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,160,000.00
Keywords
- 生殖医学
- 妊娠高血圧症候群
- オートファジー
- トロホブラスト
- 国際情報交流
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Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content
Inada, K., Shima, T., Nakashima, A., Aoki, K., Ito, M. & Saito, S., 2013, In: Journal of Reproductive Immunology. 97, 1, p. 104-111 8 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
Nakashima, A., Yamanaka-Tatematsu, M., Fujita, N., Koizumi, K., Shima, T., Yoshida, T., Nikaido, T., Okamoto, A., Yoshimori, T. & Saito, S., 2013/03, In: Autophagy. 9, 3, p. 303-316 14 p.Research output: Contribution to journal › Article › peer-review
Open Access166 Scopus citations -
Review: The role of autophagy in extravillous trophoblast function under hypoxia
Saito, S. & Nakashima, A., 2013, In: Placenta. 34, SUPPL, p. S79-S84Research output: Contribution to journal › Article › peer-review
69 Scopus citations