Analysis of innate IL-5 producing cells in immune responses and chronic inflammation

In this study, we investigated the roles of innate IL-5-producing cells in the lung and the intestine by taking advantage of IL-5/Venus knock-in mice. In response to IL-25 or IL-33, innate IL-5-producing cells rapidly produced IL-5 and IL-13. These cells were localized around bronchus and bronchioles and recruited eosinophil into the lung, suggesting that innate IL-5-producing cells play a critical role in the pathogenesis of allergic conditions. Innate IL-5-producing cells in the lung also contributed to anti-tumor immunity via eosinophil regulation. On the other hand, in the large intestine, innate IL-5-producing cells contributed to T cell-independent IgA production.