Tropism determined by gene product of Herpes Simplex Virus and host cell is a natural barrier in mother-to-infant transmission

  • Daikoku, Tohru (Principal Investigator)

Project Details

Outline of Final Research Achievements

All kinds of variant virus did not have pathogenisity in 10,000 (PFU/5uL). When the amount of 100,000 PFU or 500,000 of the virus was infected to mice, the pathogens of frame shift mutants (HSV-2 UL13 G96A fsX5, A142P fsX25, Y162V fsX141) were reduced as compared to without the mutation. On the other hand, the amino acid substitution strain (V165M) was not observed pathogenic decline.
StatusFinished
Effective start/end date2013/04/01 → 2016/03/31

Funding

  • Japan Society for the Promotion of Science: ¥5,070,000.00

Keywords

  • 感染防御学
  • 母子感染
  • 単純ヘルペスウイルス
  • HSV
  • 新生児ヘルペス

Access Project