Molecular mechanism of CYP1A2 gene expression in male regulated bygrowth hormone for personalized medicine

  • 河崎, 優希 (Principal Investigator)

Project Details

Abstract

To clarify the molecular mechanism regulating the CYP1A2 sex-specific expression, the effect of the growth hormone was examined. The continuous females specific growth hormone pattern treatment led the decreased CYP1A2 mRNA expression in the hepatocytes. The binding of Fra1 and C/EBPα to the Cyp1a2 gene 5’-flanking region was revealed.
StatusFinished
Effective start/end date2011/01/01 → 2012/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,030,000.00

Keywords

  • CYP1A2
  • 遺伝子発現制御
  • 性差
  • 遺伝子発現調節
  • 転写因子

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