Attenuatio of influenza virus by drug treatment and elucidation of mechanism of the attenuation

  • 林, 京子 (Principal Investigator)
  • 松谷, 裕二 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

The mechanism of attenuation of influenza A virus after treatment with a sphydrofuran derivative,(1R, 2R)-1-(5'-methylfur-3'-yl) propan-1, 2, 3-triol(MFPT) isolated from Streptomyces sp., was examined. The results were as follows : 1) MFPT-resistant viruses showed less pathogenicity in mice. 2) MFPTr virus clones showed lower growth in vitro. 3) Direct sequencing revealed a novel mutation in NS1 protein. 4) We tried and succeeded chemical synthesis of the compound.
StatusFinished
Effective start/end date2009/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,550,000.00

Keywords

  • インフルエンザウイルス
  • 弱毒化
  • グリセロール誘導体
  • NS1タンパク質

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