Roles of cytokines and TLRs in lymphocyte activation and differentiation

  • 高津 聖志 (Principal Investigator)
  • 長井 良憲 (Co-Investigator(Kenkyū-buntansha))
  • Ikutani, Masashi (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

To investigate IL-5-producing cells in the peripheral tissues, we succeeded to generate IL-5/GFP knock-in mice. IL-5/GFP^+ cells were distributed mainly in the lung and intestinal tissues and they were CD3^- c-kit^- cells but not CD3^+ T cells. We also analyzed RP105 signals in B cell activation and found that RP105 was required for TLR4-dependent plasma cell differentiation and IgM production. Finally, we demonstrated that an interferon-inducible gene Iigp1 had a crucial role in Th1-dependent antigen cross-presentation.
StatusFinished
Effective start/end date2008/01/012010/12/31

Funding

  • Japan Society for the Promotion of Science: ¥19,890,000.00

Keywords

  • リンパ球
  • IL-5
  • TLR
  • 抗原交叉提示
  • 免疫学
  • 自然免疫
  • IFN-γ
  • Iigp1