Research output per year
Research output per year
Project Details
Abstract
（1) Asymmetric intramolecular cycloaddition of carbonyl ylides derived from indolyl-substituted α-diazo-β-ketoesters under the influence of Rh2（S-TCPTTL)4 provided cycloadducts in up to 90% ee and with perfect endo diastereoselectivity.（2) Asymmetric intermolecular cycloaddition of carbonyl ylides derived from trichloroethyl esterpossessingα-diazo-β-ketoesters with N-methylindole using Rh2（S-TCPTTL)4 gave a 96:4 mixture of exo- and endo-cycloadducts in 96% yield with 97% ee for exo adduct.
| Status | Finished |
|---|---|
| Effective start/end date | 2010/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,030,000.00
Keywords
- インドールアルカロイド
- 不斉合成
- 付加環化反応
- カルボニルイリド
- インドール
- ロジウム(II)錯体
- 触媒反応
- タンデム反応
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Catalytic enantioselective C-H functionalization of indoles with α-diazopropionates using chiral dirhodium(II) carboxylates: Asymmetric synthesis of the (+)-α-methyl-3-indolylacetic acid fragment of acremoauxin A
Goto, T., Natori, Y., Takeda, K., Nambu, H. & Hashimoto, S., 2011/04/30, In: Tetrahedron Asymmetry. 22, 8, p. 907-915 9 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Catalytic enantioselective intermolecular cycloaddition of diazodiketoester-derived carbonyl ylides with indoles using chiral dirhodium(II) carboxylates
Shimada, N., Oohara, T., Krishnamurthi, J., Nambu, H. & Hashimoto, S., 2011/12/02, In: Organic Letters. 13, 23, p. 6284-6287 4 p.Research output: Contribution to journal › Article › peer-review
75 Scopus citations -
Continuous flow system with a polymer-supported dirhodium(II) catalyst: Application to enantioselective carbonyl ylide cycloaddition reactions
Takeda, K., Oohara, T., Shimada, N., Nambu, H. & Hashimoto, S., 2011/12/09, In: Chemistry - A European Journal. 17, 50, p. 13992-13998 7 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations