Overcome of resistance to therapy of maliganant gliomas by induction of autophagy

  • 栗本, 昌紀 (Principal Investigator)
  • 早川, 由美子 (Co-Investigator(Kenkyū-buntansha))
  • 遠藤, 俊郎 (Co-Investigator(Kenkyū-buntansha))
  • 永井, 正一 (Co-Investigator(Kenkyū-buntansha))
  • 林, 央周 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

Malignant glioma cells are resisitant to chemothereutic agents and irradiation. The resistance to apoptosis is the main mechanism of this resistance to therapy. The second programmed cell death mechanism, autophagy is now important cell death process of malignant glioma cells. The authors investigated possibility of autophagy induction of malignant glioma cells by pharmaceutical methods. Antiapoptotic drugs and autophagy inducing drugs induced glioma cell autophagy. This strategy may be a novel therapeutic method of maliganat gliomas.
StatusFinished
Effective start/end date2009/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,420,000.00

Keywords

  • 脳腫瘍学
  • 悪性グリオーマ
  • オートファジー
  • アポトーシス

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