Research output per year
Research output per year
Search results
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2024
Combined Experiments with in Vivo Fiber Photometry and Behavior Tests Can Facilitate the Measurement of Neuronal Activity in the Primary Somatosensory Cortex and Hyperalgesia in an Inflammatory Pain Mice Model
Ishikawa, T., Uta, D., Okuda, H., Potapenko, I., Hori, K., Kume, T. & Ozaki, N., 2024/03, In: Biological and Pharmaceutical Bulletin. 47, 3, p. 591-599 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mirogabalin inhibits scratching behavior of spontaneous model mouse of atopic dermatitis
Translated title of the contribution :Mirogabalin inhibits scratching behavior of spontaneous model mouse of atopic dermatitis Research output: Contribution to journal › Article
1 Scopus citations -
Photobiomodulation inhibits neuronal firing in the superficial but not deep layer of a rat spinal dorsal horn
Uta, D., Ishibashi, N., Tao, S., Sawahata, M. & Kume, T., 2024/05/28, In: Biochemical and Biophysical Research Communications. 710, 149873.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Photobiomodulation transiently increases the spontaneous firing in the superficial layer of the rat spinal dorsal horn
Translated title of the contribution :Photobiomodulation transiently increases the spontaneous firing in the superficial layer of the rat spinal dorsal horn Research output: Contribution to journal › Article
1 Scopus citations -
2023
Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression
Maki, T., Sawahata, M., Uta, D., Irie, K. & Kume, T., 2023, In: Biological and Pharmaceutical Bulletin. 46, 2, p. 359-363 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation
Taniwa, K., Murakami, K., Sakaguchi, Y., Izuo, N., Hanaki, M., Sampa, N., Kume, T., Shimizu, T. & Irie, K., 2023/10/04, In: Journal of Agricultural and Food Chemistry. 71, 39, p. 14289-14299 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Isolation and Purification of Harpagogenin as an Nrf2–ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii)
Izumi, Y., Kataoka, H., Takada-Takatori, Y., Koyama, Y., Irie, K., Akaike, A. & Kume, T., 2023, In: Biological and Pharmaceutical Bulletin. 46, 11, p. 1576-1582 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Near-Infrared Photobiomodulation of the Peripheral Nerve Inhibits the Neuronal Firing in a Rat Spinal Dorsal Horn Evoked by Mechanical Stimulation
Uta, D., Ishibashi, N., Konno, T., Okada, Y., Kawase, Y., Tao, S. & Kume, T., 2023/02, In: International Journal of Molecular Sciences. 24, 3, 2352.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Relationship between Laser Intensity at the Peripheral Nerve and Inhibitory Effect of Percutaneous Photobiomodulation on Neuronal Firing in a Rat Spinal Dorsal Horn
Uta, D., Ishibashi, N., Kawase, Y., Tao, S., Sawahata, M. & Kume, T., 2023/08, In: Journal of Clinical Medicine. 12, 15, 5126.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2022
APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression
Maki, T., Sawahata, M., Akutsu, I., Amaike, S., Hiramatsu, G., Uta, D., Izuo, N., Shimizu, T., Irie, K. & Kume, T., 2022/11, In: International Journal of Molecular Sciences. 23, 21, 13259.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Effects of naftopidil on the postsynaptic sensitivity in substantia gelatinosa neurons from lumbosacral spinal cord in rats.
Uta, D., Hattori, T., Yamada, K., Sawahata, M., Kume, T. & Yoshimura, M., 2022, In: The Journal of Functional Diagnosis of the Spinal Cord. p. 5-10Research output: Contribution to journal › Article › peer-review
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Effects of various gabapentinoids on paclitaxel-induced peripheral neuropathic pain.
Yamada, K., Uta, D., Matsuda, K., Sawahata, M. & Kume, T., 2022, In: The Journal of Functional Diagnosis of the Spinal Cord. p. 11-15Research output: Contribution to journal › Article › peer-review
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Histamine enhances ATP-induced itching and responsiveness to ATP in keratinocytes
Inami, Y., Fukushima, M., Kume, T. & Uta, D., 2022/02, In: Journal of Pharmacological Sciences. 148, 2, p. 255-261 7 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Light-Touch-Induced Afterdischarge Firing in the Superficial Spinal Dorsal Horn Neurons in Hairless Mice with Irritant Contact Dermatitis
Uta, D., Inami, Y., Fukushima, M. & Kume, T., 2022/11, In: Biological and Pharmaceutical Bulletin. 45, 11, p. 1678-1683 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38
Chikugo, A., Irie, Y., Tsukano, C., Uchino, A., Maki, T., Kume, T., Kawase, T., Hirose, K., Kageyama, Y., Tooyama, I. & Irie, K., 2022/10/05, In: ACS Chemical Neuroscience. 13, 19, p. 2913-2923 11 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation
Matsushima, Y., Irie, Y., Kageyama, Y., Bellier, J. P., Tooyama, I., Maki, T., Kume, T., Yanagita, R. C. & Irie, K., 2022/04/20, In: ChemBioChem. 23, 8, e202200029.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis
Kato, H., Sato, H., Okuda, M., Wu, J., Koyama, S., Izumi, Y., Waku, T., Iino, M., Aoki, M., Arawaka, S., Ohta, Y., Ishizawa, K., Kawasaki, K., Urano, Y., Miyasaka, T., Noguchi, N., Kume, T., Akaike, A., Sugimoto, H. & Kato, T., 2022, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 23, 7-8, p. 489-495 7 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway
Izumi, Y., Tatsumoto, A., Horiuchi, N., Arifuku, M., Uegomori, M., Kume, T. & Koyama, Y., 2022/05, In: Journal of Pharmacological Sciences. 149, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2021
Actions of local anesthetics in rat spinal dorsal horn neurons by using in vivo patch clamp recording.
Translated title of the contribution :Actions of local anesthetics in rat spinal dorsal horn neurons by using in vivo patch clamp recording. Research output: Contribution to journal › Article › peer-review
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Behavior and electrophysiology studies of the peripheral neuropathy induced by paclitaxel in mouse.
Translated title of the contribution :Behavior and electrophysiology studies of the peripheral neuropathy induced by paclitaxel in mouse. Research output: Contribution to journal › Article › peer-review
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Electrophysiological and behavioral analysis of a mouse model of atopic dermatitis.
Translated title of the contribution :Electrophysiological and behavioral analysis of a mouse model of atopic dermatitis. Research output: Contribution to journal › Article › peer-review
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Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae
Matsumoto, M., Miyamoto, M., Sawahata, M., Izumi, Y., Takada-Takatori, Y. & Kume, T., 2021/09, In: Journal of Pharmacological Sciences. 147, 1, p. 138-142 5 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Inhibitory effect of panaxytriol on BV-2 microglial cell activation
Hiramatsu, G., Uta, D., Mihara, K., Andoh, T. & Kume, T., 2021/03, In: Journal of Pharmacological Sciences. 145, 3, p. 273-278 6 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae
Sawahata, M., Izumi, Y., Akaike, A. & kume, T., 2021/08, In: Brain Research Bulletin. 173, p. 45-52 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Panaxytriol inhibits lipopolysaccharide-induced microglia activation in brain inflammation in vivo
Hiramatsu, G., Matsuda, K., Uta, D., Mihara, K. & Kume, T., 2021/07, In: Biological and Pharmaceutical Bulletin. 44, 7, p. 1024-1028 5 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2020
Chronic pain rat models enhance spontaneous glutamatergic transmission on spinal dorsal horn.
Translated title of the contribution :Chronic pain rat models enhance spontaneous glutamatergic transmission on spinal dorsal horn. Research output: Contribution to journal › Article › peer-review
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Evaluation of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator
Murakami, K., Yoshimura, M., Nakagawa, S., Kume, T., Kondo, T., Inoue, H. & Irie, K., 2020/02/02, In: International Journal of Molecular Sciences. 21, 4, 1179.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress
Delgado-Wicke, P., Rodríguez-Luna, A., Ikeyama, Y., Honma, Y., Kume, T., Gutierrez, M., Lorrio, S., Juarranz, Á. & González, S., 2020, In: Oxidative Medicine and Cellular Longevity. 2020, 2908108.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Fernblock Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes From PM 2.5-Induced Xenotoxic Stress. 
P, D.-W., A, R.-L., Y, I., Y, H., T, K., M, G., S, L., Juarranz & S., G., 2020, In: Oxidative Medicine and Cellular Longevity. 2020, p. 2908108-2908108Research output: Contribution to journal › Article › peer-review
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Protective Effect of 2′,3′-Dihydroxy-4′,6′-dimethoxychalcone on glutamate-induced neurotoxicity in primary cortical cultures
Taguchi, K., Izumi, Y., Takada-Takatori, Y., Akaike, A. & Kume, T., 2020, In: Biological and Pharmaceutical Bulletin. 43, 1, p. 184-187 4 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Protective effects of Nrf2–ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1
Inose, Y., Izumi, Y., Takada-Takatori, Y., Akaike, A., Koyama, Y., Kaneko, S. & Kume, T., 2020/09/25, In: Neuroscience Letters. 736, 135268.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology
Murakami, K., Irie, K., Yamaguchi, T., Izuo, N., Kume, T. & Hara, H., 2020/10/07, In: ACS Chemical Neuroscience. 11, 19, p. 3017-3024 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2019
Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo
Uta, D., Kato, G., Doi, A., Andoh, T., Kume, T., Yoshimura, M. & Koga, K., 2019/04/30, In: Biochemical and Biophysical Research Communications. 512, 2, p. 352-359 8 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons
Takada-Takatori, Y., Nakagawa, S., Kimata, R., Nao, Y., Mizukawa, Y., Urushidani, T., Izumi, Y., Akaike, A., Tsuchida, K. & Kume, T., 2019/12/01, In: Scientific Reports. 9, 1, 11922.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Effects of 2′-3′-dihydroxy-4′,6′-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice
Takada-Takatori, Y., Takeda, Y., Imai, R., Izumi, Y., Akaike, A., Tsuchida, K. & Kume, T., 2019/09, In: Journal of Pharmacological Sciences. 141, 1, p. 17-24 8 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Effects of Naftopidil on primary afferent fiber evoked excitatory postsynaptic transmission in adult rat substantia geratinosa neuron.
Translated title of the contribution :Effects of Naftopidil on primary afferent fiber evoked excitatory postsynaptic transmission in adult rat substantia geratinosa neuron. Research output: Contribution to journal › Article › peer-review
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Increased CCL6 expression in astrocytes and neuronal protection from neuron–astrocyte interactions
Nakagawa, S., Izumi, Y., Takada-Takatori, Y., Akaike, A. & Kume, T., 2019/11/19, In: Biochemical and Biophysical Research Communications. 519, 4, p. 777-782 6 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons
Iwasaki, M., Izuo, N., Izumi, Y., Takada-Takatori, Y., Akaike, A. & Kume, T., 2019, In: Biological and Pharmaceutical Bulletin. 42, 11, p. 1942-1946 5 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Protective Effects of 2′,3′-Dihydroxy-4′,6′-dimethoxychalcone Derived from Green Perilla Leaves against UV Radiation-Induced Cell Injury in Human Cultured Keratinocytes
Takada-Takatori, Y., Tomii, Y., Takemasa, S., Takeda, Y., Izumi, Y., Akaike, A., Tsuchida, K. & Kume, T., 2019, In: Biological and Pharmaceutical Bulletin. 42, 11, p. 1936-1941 6 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor
Yamamoto, K., Izumi, Y., Arifuku, M., Kume, T. & Sawada, H., 2019/12/01, In: Scientific Reports. 9, 1, 15977.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2018
Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation
Ikeguchi, S., Izumi, Y., Kitamura, N., Kishino, S., Ogawa, J., Akaike, A. & Kume, T., 2018/09, In: Journal of Pharmacological Sciences. 138, 1, p. 9-15 7 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons
Izumi, Y., Kataoka, H., Inose, Y., Akaike, A., Koyama, Y. & Kume, T., 2018/01/05, In: European Journal of Pharmacology. 818, p. 470-479 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2017
A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease
Izuo, N., Kasahara, C., Murakami, K., Kume, T., Maeda, M., Irie, K., Yokote, K. & Shimizu, T., 2017/12/01, In: Scientific Reports. 7, 1, 11811.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes
Makitani, K., Nakagawa, S., Izumi, Y., Akaike, A. & Kume, T., 2017/05, In: Journal of Pharmacological Sciences. 134, 1, p. 37-44 8 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons
Izumi, Y., Wakita, S., Kanbara, C., Nakai, T., Akaike, A. & Kume, T., 2017/02/08, In: Scientific Reports. 7, 42111.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8
Okuda, M., Fujita, Y., Hijikuro, I., Wada, M., Uemura, T., Kobayashi, Y., Waku, T., Tanaka, N., Nishimoto, T., Izumi, Y., Kume, T., Akaike, A., Takahashi, T. & Sugimoto, H., 2017, In: Journal of Alzheimer's Disease. 59, 1, p. 313-328 16 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Protective effect of Nrf2–ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model
Masaki, Y., Izumi, Y., Matsumura, A., Akaike, A. & Kume, T., 2017, In: European Journal of Pharmacology. 798, p. 26-34 9 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
2016
10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress
Furumoto, H., Nanthirudjanar, T., Kume, T., Izumi, Y., Park, S. B., Kitamura, N., Kishino, S., Ogawa, J., Hirata, T. & Sugawara, T., 2016/04/01, In: Toxicology and Applied Pharmacology. 296, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
51 Scopus citations -
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis
Murakami, K., Tokuda, M., Suzuki, T., Irie, Y., Hanaki, M., Izuo, N., Monobe, Y., Akagi, K. I., Ishii, R., Tatebe, H., Tokuda, T., Maeda, M., Kume, T., Shimizu, T. & Irie, K., 2016/07/04, In: Scientific Reports. 6, 29038.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Protective effect of dimethyl fumarate on an oxidative stress model induced by sodium nitroprusside in mice
Kume, T., Suenaga, A., Izumi, Y. & Akaike, A., 2016/06, In: Biological and Pharmaceutical Bulletin. 39, 6, p. 1055-1059 5 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations