Research output per year
Research output per year
- 26 results
Search results
-
2025
Investigation of the Relationship between the Chemical Stability of Itraconazole Adsorbed on Silica during Humidification and NMR Relaxation Using Time-Domain NMR
Okada, K., Hirota, M., Kumada, S. & Onuki, Y., 2025/05, In: Chemical and Pharmaceutical Bulletin. 73, 5, p. 419-426 8 p.Research output: Contribution to journal › Article › peer-review
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Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity
Okada, K., Matsumoto, R., Hara, A. & Onuki, Y., 2025/04, In: Chemical and Pharmaceutical Bulletin. 73, 4, p. 388-395 8 p.Research output: Contribution to journal › Article › peer-review
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2024
TGA and NMR relaxation measurement of nonmesoporous silica to investigate the amount of hydrolysis product in acetylsalicylic acid adsorbed on silica
Okada, K., Watanabe, D., Ono, T., Hayashi, Y., Kumada, S. & Onuki, Y., 2024/04/15, In: Journal of Pharmaceutical and Biomedical Analysis. 241, 115972.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Use of Time-Domain NMR for 1H T1 Relaxation Measurement and Fitting Analysis in Homogeneity Evaluation of Amorphous Solid Dispersion
Okada, K., Ono, T., Hayashi, Y., Kumada, S. & Onuki, Y., 2024/03, In: Journal of Pharmaceutical Sciences. 113, 3, p. 680-687 8 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2023
A Data-Driven Approach to Predicting Tablet Properties after Accelerated Test Using Raw Material Property Database and Machine Learning
Hayashi, Y., Nakano, Y., Marumo, Y., Kumada, S., Okada, K. & Onuki, Y., 2023/06/01, In: Chemical and Pharmaceutical Bulletin. 71, 6, p. 406-415 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Tsuji, T., Ono, T., Taguchi, H., Leong, K. H., Hayashi, Y., Kumada, S., Okada, K. & Onuki, Y., 2023/07/01, In: Chemical and Pharmaceutical Bulletin. 71, 7, p. 576-583 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Determination of the Solid Content of Active Pharmaceutical Ingredient Powders in Suspension-Type Pharmaceutical Oral Jelly Using Time-Domain NMR
Kobayashi, R., Ono, T., Kumada, S., Okada, K. & Onuki, Y., 2023/10/01, In: Chemical and Pharmaceutical Bulletin. 71, 11, p. 838-842 5 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Usefulness of Applying Partial Least Squares Regression to T2 Relaxation Curves for Predicting the Solid form Content in Binary Physical Mixtures
Chiba, Y., Okada, K., Hayashi, Y., Kumada, S. & Onuki, Y., 2023/04, In: Journal of Pharmaceutical Sciences. 112, 4, p. 1041-1051 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2022
Characterization of the Salt and Free Base of Active Pharmaceutical Ingredients Based on NMR Relaxometry Measured by Time Domain NMR
Chiba, Y., Okada, K., Hayashi, Y., Leong, K. H., Kumada, S. & Onuki, Y., 2022/02/01, In: Chemical and Pharmaceutical Bulletin. 70, 2, p. 162-168 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR
Tsuji, T., Kobayashi, R., Hayashi, Y., Kumada, S., Mizuguchi, M., Okada, K. & Onuki, Y., 2022/08/01, In: Chemical and Pharmaceutical Bulletin. 70, 8, p. 558-565 8 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The Molded Tablet, a disintegrant-free orally disintegrating tablet, resists thickening solution-reduced drug dissolution
Onuki, Y., Sugiura, D., Kumada, S., Kobayashi, R., Nakamura, T., Kogawa, T., Sakai, H. & Okada, K., 2022/03, In: Journal of Drug Delivery Science and Technology. 69, 103179.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2021
Application of machine learning to a material library for modeling of relationships between material properties and tablet properties
Hayashi, Y., Nakano, Y., Marumo, Y., Kumada, S., Okada, K. & Onuki, Y., 2021/11/20, In: International Journal of Pharmaceutics. 609, 121158.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design
Usuda, S., Masukawa, N., Leong, K. H., Okada, K. & Onuki, Y., 2021/09/01, In: Chemical and Pharmaceutical Bulletin. 69, 9, p. 896-904 9 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Incompatibility of remimazolam besylate with Ringer's acetate infusion resulting in total occlusion of an intravenous catheter
Matsuo, M., Okada, K., Onuki, Y. & Yamazaki, M., 2021/04/15, In: BMJ Case Reports. 14, 4Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules
Okada, K., Hayashi, Y., Kumada, S. & Onuki, Y., 2021/09/01, In: European Journal of Pharmaceutical Sciences. 164, 105908.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules
Ohgi, K., Hayashi, Y., Tsuji, T., Ito, T., Leong, K. H., Usuda, S., Kumada, S., Okada, K. & Onuki, Y., 2021/07/15, In: International Journal of Pharmaceutics. 604, 120770.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2020
Effect of different direct compaction grades of mannitol on the storage stability of tablet properties investigated using a kohonen self-organizing map and elastic net regression model
Kosugi, A., Leong, K. H., Urata, E., Hayashi, Y., Kumada, S., Okada, K. & Onuki, Y., 2020/09, In: Pharmaceutics. 12, 9, p. 1-14 14 p., 886.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions
Ougi, K., Okada, K., Leong, K. H., Hayashi, Y., Kumada, S. & Onuki, Y., 2020/11/01, In: European Journal of Pharmaceutical Sciences. 154, 105502.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
2019
1H NMR Relaxation Study to Evaluate the Crystalline State of Active Pharmaceutical Ingredients Containing Solid Dosage Forms Using Time Domain NMR
Okada, K., Hirai, D., Kumada, S., Kosugi, A., Hayashi, Y. & Onuki, Y., 2019/01, In: Journal of Pharmaceutical Sciences. 108, 1, p. 451-456 6 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
A novel approach to evaluate amorphous-to-crystalline transformation of active pharmaceutical ingredients in solid dispersion using time-domain NMR
Okada, K., Hirai, D., Hayashi, Y., Kumada, S., Kosugi, A. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 3, p. 265-270 6 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
A time-domain NMR study of the state of water in wet granules with different fillers and its contribution to the wet granulation process and to the characteristics of granules
Ito, T., Okada, K., Leong, K. H., Hirai, D., Hayashi, Y., Kumada, S., Kosugi, A. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 3, p. 271-276 6 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Time–temperature superposition principle for the kinetic analysis of destabilization of pharmaceutical emulsions
Tsuji, T., Mochizuki, K., Okada, K., Hayashi, Y., Obata, Y., Takayama, K. & Onuki, Y., 2019/05/30, In: International Journal of Pharmaceutics. 563, p. 406-412 7 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2018
Inhibition of gastric H+,K+-ATPase activity in vitro by dissolution media of original brand-name and generic tablets of lansoprazole, a proton pump inhibitor
Phutthatiraphap, S., Hayashi, Y., Fujii, T., Kosugi, A., Okada, K., Kadozaki, T., Ishise, T., Sakai, H. & Onuki, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 9, p. 896-900 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
MRI monitoring of the mixed state of admixtures consisting of moisturizing cream and steroid ointment during the mixing process by a revolution/rotation-type hybrid mixer
Yokokawa, M., Setoyama, H., Okada, K., Hayashi, Y., Machida, Y., Onuki, Y. & Obata, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 11, p. 1078-1082 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Nondestructive Monitoring of the Dispersion State of Titanium Dioxide Nanoparticles in Concentrated Suspensions Using Magnetic Resonance Imaging
Ito, T., Kida, C., Okada, K., Ikeda, J., Otomura, K., Hayashi, Y., Obata, Y., Takayama, K. & Onuki, Y., 2018/10/09, In: Langmuir. 34, 40, p. 12093-12099 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2012
Formation of higher-order structures of chiral poly(ethynylpyridine)s depending on size, temperature, and saccharide recognition
Abe, H., Okada, K., Makida, H. & Inouye, M., 2012/09/14, In: Organic and Biomolecular Chemistry. 10, 34, p. 6930-6936 7 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations