Projects per year
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Dive into the research topics where Gene Regulation is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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mRNAキャップ特異的m6Amメチル化酵素PCIF1による遺伝子発現制御機構の解明
Hirose, Y. (Principal Investigator) & Tanaka, A. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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Regulation of mRNA metabolism by the transcription-coupled RNA methyltransferase PCIF1
Hirose, Y. (PI)
2017/04/01 → 2020/03/31
Project: Research
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Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity
Sugita, A., Kano, R., Ishiguro, H., Yanagisawa, N., Kuruma, S., Wani, S., Tanaka, A., Tabuchi, Y., Ohkuma, Y. & Hirose, Y., 2024/10, In: Cells. 13, 20, 1689.Research output: Contribution to journal › Article › peer-review
Open Access -
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants
Zarate, Y. A., Uehara, T., Abe, K., Oginuma, M., Harako, S., Ishitani, S., Lehesjoki, A. E., Bierhals, T., Kloth, K., Ehmke, N., Horn, D., Holtgrewe, M., Anderson, K., Viskochil, D., Edgar-Zarate, C. L., Sacoto, M. J. G., Schnur, R. E., Morrow, M. M., Sanchez-Valle, A. & Pappas, J. & 14 others, , 2021/06, In: Genetics in Medicine. 23, 6, p. 1050-1057 8 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The cap-specific m6A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner
Sugita, A., Kuruma, S., Yanagisawa, N., Ishiguro, H., Kano, R., Ohkuma, Y. & Hirose, Y., 2021/08/01, In: Journal of Biochemistry. 170, 2, p. 203-213 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations
Datasets
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Crystal structure of the human cap-specific adenosine methyltransferase bound to SAH
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRW/pdb, https://www.wwpdb.org/pdb?id=pdb_00006irw
Dataset
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Solution structure of the complex between TFIIE alpha C-terminal acidic domain and TFIIH p62 PH domain
Okuda, M. (Contributor), Tanaka, A. (Contributor), Satoh, M. (Contributor), Mizuta, S. (Contributor), Takazawa, M. (Contributor), Ohkuma, Y. (Contributor) & Nishimura, Y. (Contributor), Protein Data Bank (PDB), 2008/04/01
DOI: 10.2210/pdb2RNR/pdb, https://www.wwpdb.org/pdb?id=pdb_00002rnr
Dataset
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Crystal structure of the zebrafish cap-specific adenosine methyltransferase
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRX/pdb, https://www.wwpdb.org/pdb?id=pdb_00006irx
Dataset