Valacyclovir neurotoxicity: Clinical experience and review of the literature

T. Asahi*, M. Tsutsui, M. Wakasugi, D. Tange, C. Takahashi, K. Tokui, S. Okazawa, H. Okudera

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

68 被引用数 (Scopus)

抄録

Valacyclovir (VACV) is used increasingly to treat herpes zoster, although neuropsychiatric symptoms [VACV neurotoxicity (VAN) or acyclovir neurotoxicity], may accompany use of this drug. To promote awareness of this rare condition, we describe here two clinical cases of VAN we previously reported and review 20 cases from the literature. In all cases, chronic or acute renal failure preceded VAN. The symptoms of VAN varied, but disturbances of consciousness and hallucination occurred most commonly. When acute renal failure was due to the drug, recovery from both the disturbance of consciousness and renal failure followed within several days after discontinuation of VACV. Early recognition and diagnosis will ensure effective treatment of VAN.

本文言語英語
ページ(範囲)457-460
ページ数4
ジャーナルEuropean Journal of Neurology
16
4
DOI
出版ステータス出版済み - 2009/04

ASJC Scopus 主題領域

  • 神経学
  • 臨床神経学

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