抄録
Background: Although J-wave elevation in the inferolateral leads could be related to idiopathic ventricular fibrillation (IVF), little is known about the pathophysiologic characteristics of J-wave elevation in patients with IVF. Objective: This study aimed to determine the relationship between augmentation of J-wave elevation and changes in RR interval or autonomic nervous activities in patients with IVF. Methods: Eight patients with IVF and 22 controls with J-wave elevation (<0.1 mV) in lead V5 were studied. The J-wave amplitude was automatically measured in lead CM5 of a digital Holter electrocardiogram, and the JRR relationship was determined. Based on the analysis of heart rate variability, the relationship between the J-wave amplitude and the natural logarithm of high-frequency (HF) components (Jln HF relationship) or the ratio of low frequency (LF) components to HF components (JLF/HF relationship) was also determined. Results: The JRR slope (mm/s) was greater in patients with IVF than in controls (3.5 ± 0.7 vs 2.4 ± 0.8; P <.01), as was J-wave amplitude (mm) at an RR interval of 1.2 seconds (2.8 ± 0.9 vs 2.0 ± 0.6; P <.05). The J-wave amplitude was correlated positively with ln HF and negatively with LF/HF, and the slopes of both Jln HF and JLF/HF regression lines were greater in patients with IVF than in controls. During an entire 24-hour period, there was no difference between the 2 groups in either HF or LF/HF. Nine of the total 11 episodes (82%) of spontaneous ventricular fibrillation occurred between 18:00 and 6:00. Conclusions: In patients with IVF as compared with control subjects, J-wave elevation was more strongly augmented during bradycardia and was associated with an increase in vagal activity. This could be related to the occurrence of ventricular fibrillation predominantly at night in patients with IVF.
本文言語 | 英語 |
---|---|
ページ(範囲) | 249-255 |
ページ数 | 7 |
ジャーナル | Heart Rhythm |
巻 | 9 |
号 | 2 |
DOI | |
出版ステータス | 出版済み - 2012/02 |
ASJC Scopus 主題領域
- 循環器および心血管医学
- 生理学(医学)