Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac

Suresh Awale; Jun Ya Ueda; Sirivan Athikomkulchai; Dya Fita Dibwe; Sherif Abdelhamed; Satoru Yokoyama; Ikuo Saiki; Ryuta Miyatake

doi:10.1021/np300596c

Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac

Suresh Awale^*, Jun Ya Ueda, Sirivan Athikomkulchai, Dya Fita Dibwe, Sherif Abdelhamed, Satoru Yokoyama, Ikuo Saiki, Ryuta Miyatake

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

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Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.

本文言語	英語
ページ（範囲）	1999-2002
ページ数	4
ジャーナル	Journal of Natural Products
巻	75
号	11
DOI	https://doi.org/10.1021/np300596c
出版ステータス	出版済み - 2012/11/26

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/np300596c

引用スタイル

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title = "Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac",

abstract = "Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.",

author = "Suresh Awale and Ueda, {Jun Ya} and Sirivan Athikomkulchai and Dibwe, {Dya Fita} and Sherif Abdelhamed and Satoru Yokoyama and Ikuo Saiki and Ryuta Miyatake",

year = "2012",

month = nov,

day = "26",

doi = "10.1021/np300596c",

language = "英語",

volume = "75",

pages = "1999--2002",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac

AU - Awale, Suresh

AU - Ueda, Jun Ya

AU - Athikomkulchai, Sirivan

AU - Dibwe, Dya Fita

AU - Abdelhamed, Sherif

AU - Yokoyama, Satoru

AU - Saiki, Ikuo

AU - Miyatake, Ryuta

PY - 2012/11/26

Y1 - 2012/11/26

N2 - Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.

AB - Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.

UR - http://www.scopus.com/inward/record.url?scp=84870167887&partnerID=8YFLogxK

U2 - 10.1021/np300596c

DO - 10.1021/np300596c

M3 - 学術論文

C2 - 23092429

AN - SCOPUS:84870167887

SN - 0163-3864

VL - 75

SP - 1999

EP - 2002

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac

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ASJC Scopus 主題領域

UN SDG

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