Urine aquaporin-2: A promising marker of response to the arginine vasopressin type-2 antagonist, Tolvaptan in patients with congestive heart failure

Teruhiko Imamura, Koichiro Kinugawa*

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

21 被引用数 (Scopus)

抄録

Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney. The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients with decompensated heart failure refractory to conventional diuretics. However, the ideal responders to tolvaptan have not yet been identified, and non-responders experience worse clinical courses despite treatment with tolvaptan. Urine aquaporin-2 has recently been demonstrated as a promising predictor of response to tolvaptan. We here validated aquaporin-2-guided tolvaptan therapy in patients with decompensated heart failure. Long-term efficacy of tolvaptan treatment in the responders defined by aquaporin-2 needs to be validated in the future prospective study.

本文言語英語
論文番号105
ジャーナルInternational Journal of Molecular Sciences
17
1
DOI
出版ステータス出版済み - 2016/01/14

ASJC Scopus 主題領域

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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