TY - JOUR
T1 - Two new cyclopentenones and a new furanone from Baeckea frutescens and their cytotoxicities
AU - Ito, Takuya
AU - Nisa, Khoirun
AU - Kodama, Takeshi
AU - Tanaka, Masami
AU - Okamoto, Yasuko
AU - Ismail,
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Two new cyclopentenones, frutescencenones A (1) and B (2), and a new furanone derivative, frutescencenone C (3), together with two known cyclopentenones (4 and 5), were isolated from the leaves of Baeckea frutescens. Their structures were deduced by comprehensive spectroscopic analyses, including 1D and 2D NMR, and HREIMS data. Frutescencenone A (1) showed moderate growth inhibitory activity against human lung A549, pancreatic PSN-1, and breast MDA-MB-231 cancer cell lines, with IC50 values of 36.3 μM, 38.2 μM, and 29.3 μM, respectively. In contrast, frutescencenone C (3) showed selective cytotoxic activity against PSN-1, with an IC50 value of 20.1 μM.
AB - Two new cyclopentenones, frutescencenones A (1) and B (2), and a new furanone derivative, frutescencenone C (3), together with two known cyclopentenones (4 and 5), were isolated from the leaves of Baeckea frutescens. Their structures were deduced by comprehensive spectroscopic analyses, including 1D and 2D NMR, and HREIMS data. Frutescencenone A (1) showed moderate growth inhibitory activity against human lung A549, pancreatic PSN-1, and breast MDA-MB-231 cancer cell lines, with IC50 values of 36.3 μM, 38.2 μM, and 29.3 μM, respectively. In contrast, frutescencenone C (3) showed selective cytotoxic activity against PSN-1, with an IC50 value of 20.1 μM.
KW - Baeckea frutescens
KW - Cyclopentenone
KW - Cytotoxic activity
KW - Furanone
KW - Myrtaceae
UR - http://www.scopus.com/inward/record.url?scp=84974555779&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2016.05.017
DO - 10.1016/j.fitote.2016.05.017
M3 - 学術論文
C2 - 27262787
AN - SCOPUS:84974555779
SN - 0367-326X
VL - 112
SP - 132
EP - 135
JO - Fitoterapia
JF - Fitoterapia
ER -
