TY - JOUR
T1 - Total synthesis of A-nor B-aromatic OSW-1 aglycon
T2 - A highly effective approach to optically active trans-4,5-benzhydrindane
AU - Matsuya, Yuji
AU - Itoh, Takakatsu
AU - Nemoto, Hideo
PY - 2003/6
Y1 - 2003/6
N2 - A new enantioselective approach to the trans-4,5-benzhydrindane skeleton by intramolecular cycloaddition of o-quinodimethane, generated by thermolysis of a benzocyclobutene derivative, is described. Using this method, the synthesis of the A-nor B-aromatic aglycon of OSW-1, a potent antitumor saponin, was accomplished. (
AB - A new enantioselective approach to the trans-4,5-benzhydrindane skeleton by intramolecular cycloaddition of o-quinodimethane, generated by thermolysis of a benzocyclobutene derivative, is described. Using this method, the synthesis of the A-nor B-aromatic aglycon of OSW-1, a potent antitumor saponin, was accomplished. (
KW - Antitumor agents
KW - Cycloaddition
KW - Diastereoselectivity
KW - Steroids
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=0038730487&partnerID=8YFLogxK
U2 - 10.1002/ejoc.200300140
DO - 10.1002/ejoc.200300140
M3 - 学術論文
AN - SCOPUS:0038730487
SN - 1434-193X
SP - 2221
EP - 2224
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 12
ER -