Therapeutic index of methotrexate depends on circadian cycling of tumour necrosis factor-α in collagen-induced arthritic rats and mice

Keyphrases

• Tumor Necrosis Factor-α 100%
• Rheumatoid Arthritis 100%
• Methotrexate 100%
• Collagen-induced 100%
• Therapeutic Index 100%
• Arthritic Rats 100%
• 24-h Rhythm 75%
• Dosing Time 75%
• Arthritis 75%
• Dark Phase 50%
• Effective Treatment 25%
• Symptomatology 25%
• Autoimmune Disease 25%
• Time Dependency 25%
• Collagen 25%
• Unknown Etiology 25%
• Rheumatoid Arthritis Patients 25%
• Light Phase 25%
• Morning Stiffness 25%
• Time-based 25%
• Antirheumatic Drugs 25%
• Rheumatoid Arthritis Treatment 25%
• Optimal Dosing 25%
• Arthritis Score 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Methotrexate 100%
• Rheumatoid Arthritis 100%
• Tumor Necrosis 100%
• Therapeutic Window 100%
• Inflammatory Arthritis 100%
• Arthritis 66%
• Autoimmune Disease 16%
• Antirheumatic Agent 16%
• Symptomatology 16%
• Morning Stiffness 16%

Immunology and Microbiology

• Tumor Necrosis Factor 100%
• Inflammatory Arthritis 100%
• Methotrexate 100%
• Rhythm 83%
• Arthritis 66%
• Blood Plasma 16%
• Blood Level 16%
• Rigidity 16%
• Autoimmune Disease 16%