The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes

Jian Pan; Tsumoru Morimoto; Hideyuki Kobayashi; Hiroki Tanimoto; Kiyomi Kakiuchi

doi:10.3987/COM-19-14064

The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes

Jian Pan, Tsumoru Morimoto^*, Hideyuki Kobayashi, Hiroki Tanimoto, Kiyomi Kakiuchi

^*この論文の責任著者

生体認識化学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

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An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.

本文言語	英語
ページ（範囲）	519-533
ページ数	15
ジャーナル	Heterocycles
巻	98
号	4
DOI	https://doi.org/10.3987/COM-19-14064
出版ステータス	出版済み - 2019

ASJC Scopus 主題領域

分析化学
薬理学
有機化学

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10.3987/COM-19-14064

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title = "The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes",

abstract = "An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.",

author = "Jian Pan and Tsumoru Morimoto and Hideyuki Kobayashi and Hiroki Tanimoto and Kiyomi Kakiuchi",

note = "Publisher Copyright: {\textcopyright} 2019 The Japan Institute of Heterocyclic Chemistry.",

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doi = "10.3987/COM-19-14064",

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T1 - The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes

AU - Pan, Jian

AU - Morimoto, Tsumoru

AU - Kobayashi, Hideyuki

AU - Tanimoto, Hiroki

AU - Kakiuchi, Kiyomi

PY - 2019

Y1 - 2019

N2 - An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.

AB - An accessible protocol for the linear-selective hydroformylation of vinylheteroarenes using formaldehyde as a substitute for syngas is reported. The simultaneous use of BIPHEP and Nixantphos ligands permitted a high regioselectivity (linear/branched = up to 93/7) and moderate yield of isolated product (up to 84%) to be obtained. Under such catalytic conditions, vinylheteroarenes containing a vinyl group at the 2-position in the heterocycle ring reacted more linear-selectively with formaldehyde than at the 3-position.

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M3 - 学術論文

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JO - Heterocycles

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ER -

The use of formaldehyde in the rhodium-catalyzed linear-selective hydroformylation of vinylheteroarenes

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