The role of phosphorylation cascade in insulin action

K. Tobe; K. Ueki; H. Tamemoto; Y. Kaburagi; R. Honda; T. Kadowaki

The role of phosphorylation cascade in insulin action

K. Tobe^*, K. Ueki, H. Tamemoto, Y. Kaburagi, R. Honda, T. Kadowaki

^*この論文の責任著者

内科学（第一）講座

研究成果: ジャーナルへの寄稿 › 総説 › 査読

1 被引用数 (Scopus)

抄録

Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

本文言語	英語
ページ（範囲）	2673-2685
ページ数	13
ジャーナル	Nihon rinsho. Japanese journal of clinical medicine
巻	52
号	10
出版ステータス	出版済み - 1994/10

ASJC Scopus 主題領域

医学一般

引用スタイル

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abstract = "Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.",

author = "K. Tobe and K. Ueki and H. Tamemoto and Y. Kaburagi and R. Honda and T. Kadowaki",

year = "1994",

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TY - JOUR

T1 - The role of phosphorylation cascade in insulin action

AU - Tobe, K.

AU - Ueki, K.

AU - Tamemoto, H.

AU - Kaburagi, Y.

AU - Honda, R.

AU - Kadowaki, T.

PY - 1994/10

Y1 - 1994/10

N2 - Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

AB - Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl inositol 3-kinase activity, and ras activity. MAP kinase cascade activated by ras, 70kDaS6 kinase lying downstream of PI3-kinase, and the regulation of glycogen synthase have been discussed.

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M3 - 総説

C2 - 7983797

AN - SCOPUS:0028528033

SN - 0047-1852

VL - 52

SP - 2673

EP - 2685

JO - Nihon rinsho. Japanese journal of clinical medicine

JF - Nihon rinsho. Japanese journal of clinical medicine

IS - 10

ER -

The role of phosphorylation cascade in insulin action

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ASJC Scopus 主題領域

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