The liver in itai-itai disease (chronic cadmium poisoning): Pathological features and metallothionein expression

Hayato Baba, Koichi Tsuneyama*, Megumi Yazaki, Kohei Nagata, Takashi Minamisaka, Tatsuhiro Tsuda, Kazuhiro Nomoto, Shinichi Hayashi, Shigeharu Miwa, Takahiko Nakajima, Yuko Nakanishi, Keiko Aoshima, Joji Imura

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

143 被引用数 (Scopus)

抄録

Cadmium (Cd) is a highly hepatotoxic heavy metal, which is widely dispersed in the environment. Acute Cd hepatotoxicity has been well studied in experimental animals; however, effects of prolonged exposure to Cd doses on the liver remain unclear. In the present study, to evaluate chronic Cd hepatotoxicity, we examined specimens from cases of itai-itai disease, the most severe form of chronic Cd poisoning. We compared 89 cases of itai-itai disease with 27 control cases to assess Cd concentration in organs. We also examined 80 cases of itai-itai disease and 70 control cases for histopathological evaluation. In addition, we performed immunohistochemistry for metallothionein, which binds and detoxifies Cd. Hepatic Cd concentration was higher than Cd concentration in all other organs measured in the itai-itai disease group, whereas it was second highest following renal concentration in the control group. In the liver in the itai-itai disease group, fibrosis was observed at a significantly higher rate than that in the control group. Metallothionein expression was significantly higher in the itai-itai disease group than that in the control group. Prolonged exposure to low doses of Cd leads to high hepatic accumulation, which can then cause fibrosis; however, it also causes high expression of metallothionein, which is thought to reduce Cd hepatotoxicity.

本文言語英語
ページ(範囲)1228-1234
ページ数7
ジャーナルModern Pathology
26
9
DOI
出版ステータス出版済み - 2013/09

ASJC Scopus 主題領域

  • 医学一般

フィンガープリント

「The liver in itai-itai disease (chronic cadmium poisoning): Pathological features and metallothionein expression」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル