The α-spectrin gene is on chromosome 1 in mouse and man

K. Huebner; A. P. Palumbo; M. Isobe; C. A. Kozak; S. Monaco; G. Rovera; C. M. Croce; P. J. Curtis

doi:10.1073/pnas.82.11.3790

The α-spectrin gene is on chromosome 1 in mouse and man

K. Huebner, A. P. Palumbo, M. Isobe, C. A. Kozak, S. Monaco, G. Rovera, C. M. Croce, P. J. Curtis

工学科　生命工学コース

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

69 被引用数 (Scopus)

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By using α-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for α-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse α-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the α-spectrin locus in mouse with the sph locus which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human α-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.

本文言語	英語
ページ（範囲）	3790-3793
ページ数	4
ジャーナル	Proceedings of the National Academy of Sciences of the United States of America
巻	82
号	11
DOI	https://doi.org/10.1073/pnas.82.11.3790
出版ステータス	出版済み - 1985

ASJC Scopus 主題領域

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10.1073/pnas.82.11.3790

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title = "The α-spectrin gene is on chromosome 1 in mouse and man",

abstract = "By using α-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for α-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse α-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the α-spectrin locus in mouse with the sph locus which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human α-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.",

author = "K. Huebner and Palumbo, {A. P.} and M. Isobe and Kozak, {C. A.} and S. Monaco and G. Rovera and Croce, {C. M.} and Curtis, {P. J.}",

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doi = "10.1073/pnas.82.11.3790",

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T1 - The α-spectrin gene is on chromosome 1 in mouse and man

AU - Huebner, K.

AU - Palumbo, A. P.

AU - Isobe, M.

AU - Kozak, C. A.

AU - Monaco, S.

AU - Rovera, G.

AU - Croce, C. M.

AU - Curtis, P. J.

PY - 1985

Y1 - 1985

N2 - By using α-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for α-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse α-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the α-spectrin locus in mouse with the sph locus which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human α-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.

AB - By using α-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for α-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse α-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the α-spectrin locus in mouse with the sph locus which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human α-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.

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DO - 10.1073/pnas.82.11.3790

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AN - SCOPUS:0022416520

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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The α-spectrin gene is on chromosome 1 in mouse and man

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