Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar

Nwet Nwet Win*, So Yeun Woo, Hla Ngwe, Prema, Chin Piow Wong, Takuya Ito, Yasuko Okamoto, Masami Tanaka, Hiroshi Imagawa, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

20 被引用数 (Scopus)

抄録

Two new tetrahydrofuran lignans, taungtangyiols A (1) and B (2), and eight known furofuran lignans (3−10), were isolated from the chloroform extract of Premna integrifolia wood collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. The X-ray crystal structure of 1 clearly indicated its relative configuration. Taungtangyiols A (1) and B (2) inhibited the deposition of melanin in B16F10 mouse melanoma cells, with IC50 values of 50.7 and 40.9 μM, respectively, without notable cytotoxicity. An SAR study demonstrated that the furofuran and dioxymethylene moieties of the lignans play a vital role in inhibiting melanogenesis.

本文言語英語
ページ(範囲)308-313
ページ数6
ジャーナルFitoterapia
127
DOI
出版ステータス出版済み - 2018/06

ASJC Scopus 主題領域

  • 薬理学
  • 創薬

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