Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes

Supaart Sirikantaramas, Futoshi Taura*, Yumi Tanaka, Yu Ishikawa, Satoshi Morimoto, Yukihiro Shoyama

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

191 被引用数 (Scopus)

抄録

Tetrahydrocannabinolic acid (THCA) synthase is the enzyme responsible for the production of tetrahydrocannabinol (THC), the psychoactive component of marijuana (Cannabis sativa L.). We suggest herein that THCA is biosynthesized in the storage cavity of the glandular trichomes based on the following observations. (i) The exclusive expression of THCA synthase was confirmed in the secretory cells of glandular trichomes by reverse transcription-PCR (RT-PCR) analysis. (ii) THCA synthase activity was detected in the storage cavity content. (iii) Transgenic tobacco expressing THCA synthase fused to green fluorescent protein showed fluorescence in the trichome head corresponding to the storage cavity. These results also showed that secretory cells of the glandular trichomes secrete not only metabolites but also biosynthetic enzyme.

本文言語英語
ページ(範囲)1578-1582
ページ数5
ジャーナルPlant and Cell Physiology
46
9
DOI
出版ステータス出版済み - 2005/09

ASJC Scopus 主題領域

  • 生理学
  • 植物科学
  • 細胞生物学

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