T‐Cell Receptors Are Expressed but Down‐Regulated on Intradecidual T Lymphocytes

TAKESHI MORII*, KIYOSHI NISHIKAWA, SHIGERU SAITO, MASAHIRO ENOMOTO, AYAKO ITO, NOBUO KURAI, TAKETO SHIMOYAMA, MOTOHIKO ICHIJO, NOBUHIRO NARITA

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

43 被引用数 (Scopus)

抄録

PROBLEM: Dietl et al. considered “intradecidual T cell tolerance towards fetal antigens” with their observation that intradecidual T cells lack immunohistochemically detectable amounts of T cell receptor (TCR) molecules while expressing normal amounts of CD3 molecules during early normal pregnancy. METHOD: To reevaluate these findings we examined the TCR and CD3 expression on intradecidual T cells using flow cytometry. CONCLUSIONS: In our study, all intradecidual CD3+ T cells expressed either TCR αβ or TCR γδ. However, the expression of the CD3/TCR complex on intradecidual T cells was down‐regulated. The level of CD3/TCR complex expression on intradecidual T cells was about two‐thirds of that on peripheralblood T cells. Further, the proportions of αβ + and γδ + cells in CD3 + cells did not significantly differ between decidua and peripheral blood. 1993 Munksgaard

本文言語英語
ページ(範囲)1-4
ページ数4
ジャーナルAmerican Journal of Reproductive Immunology
29
1
DOI
出版ステータス出版済み - 1993/01

ASJC Scopus 主題領域

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

フィンガープリント

「T‐Cell Receptors Are Expressed but Down‐Regulated on Intradecidual T Lymphocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル