Synthesis of the C20-C34 segment of the immunosuppressant FK-506 via stereocontrolled aldol coupling application of a remote chelation effect

Keyphrases

• Stereocontrolled 100%
• FK506 100%
• Aldol Coupling 100%
• Chelation Effect 100%
• Tight 50%
• Stereoselectivity 50%
• Quinolinic Acid 50%
• Lithium Enolate 50%
• Methyl Ethyl Ketone 50%
• Trityl Ethers 50%
• Aldol Condensation 50%
• Stereoselection 50%
• Chiral Aldehydes 50%
• Ethyl (R)-3-hydroxybutyrate 50%
• Ketone Enolates 50%

Chemistry

• Enolates 100%
• Chelation 100%
• Immunosuppressive Agent 100%
• Lithium 50%
• Ketone 50%
• Ethyl 50%
• (R)-3-Hydroxybutyrate 50%
• Methyl Ketone 50%
• (-)-Quinic Acid 50%
• Aldol Condensation 50%