Synthesis, characterization and bio-activity of nickel(II) and copper(II) complexes of a bidentate NS Schiff base of S-benzyl dithiocarbazate

E. Zangrando*, M. T. Islam, M. Al Amin A.A. Islam, M. C. Sheikh, M. T.H. Tarafder, R. Miyatake, R. Zahan, M. A. Hossain

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

76 被引用数 (Scopus)

抄録

The reaction of S-benzyldithiocarbazate (SBDTC) with 3-hydroxyacetophenone afforded a bidentate NS Schiff base HL (HL = benzyl-3-(3-hydroxyphenyl methyl ethylene)hydrazine carbodithioate) which on further reaction with nickel(II) and copper(II) salt yielded bis-chelated inner complexes, NiL2 and CuL2, respectively with deprotonated L ligand. The ligand and its complexes were characterized by physico-chemical techniques, viz., molar conductance, magnetic susceptibility measurement, IR, NMR, UV-Vis spectroscopy and mass spectroscopic techniques. The crystal structure of all the compounds was also characterized by single crystal X-ray crystallography. The ligand exists in its thione tautomeric form both in solution and in the solid state. In the complexes the two deprotonated ligands chelate the metal through the azomethine nitrogen and the thione sulfur atom with cis arrangement generating a tetrahedrally distorted square planar geometry around the metal center. Only complex CuL2 showed moderate analgesic activity at 60 min compared to Diclofenac sodium, while all the test compounds exhibited good anti-inflammatory activity as compared to standard drug Indomethacin.

本文言語英語
ページ(範囲)278-284
ページ数7
ジャーナルInorganica Chimica Acta
427
DOI
出版ステータス出版済み - 2015/03/01

ASJC Scopus 主題領域

  • 物理化学および理論化学
  • 無機化学
  • 材料化学

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