Synthesis and pharmacological profile of serofendic acids A and B

Taro Terauchi; Naoki Asai; Takashi Doko; Ryota Taguchi; Osamu Takenaka; Hideki Sakurai; Masahiro Yonaga; Teiji Kimura; Akiharu Kajiwara; Tetsuhiro Niidome; Toshiaki Kume; Akinori Akaike; Hachiro Sugimoto

doi:10.1016/j.bmc.2007.07.037

Synthesis and pharmacological profile of serofendic acids A and B

Taro Terauchi^*, Naoki Asai, Takashi Doko, Ryota Taguchi, Osamu Takenaka, Hideki Sakurai, Masahiro Yonaga, Teiji Kimura, Akiharu Kajiwara, Tetsuhiro Niidome, Toshiaki Kume, Akinori Akaike, Hachiro Sugimoto

^*この論文の責任著者

応用薬理学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

抄録

We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.

本文言語	英語
ページ（範囲）	7098-7107
ページ数	10
ジャーナル	Bioorganic and Medicinal Chemistry
巻	15
号	22
DOI	https://doi.org/10.1016/j.bmc.2007.07.037
出版ステータス	出版済み - 2007/11/15

ASJC Scopus 主題領域

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

文献へのアクセス

10.1016/j.bmc.2007.07.037

引用スタイル

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title = "Synthesis and pharmacological profile of serofendic acids A and B",

abstract = "We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.",

keywords = "Atisane, Glutamate, Neurodegenerative disease, Neuroprotective, Neurotoxicity, Serofendic acid",

author = "Taro Terauchi and Naoki Asai and Takashi Doko and Ryota Taguchi and Osamu Takenaka and Hideki Sakurai and Masahiro Yonaga and Teiji Kimura and Akiharu Kajiwara and Tetsuhiro Niidome and Toshiaki Kume and Akinori Akaike and Hachiro Sugimoto",

year = "2007",

month = nov,

day = "15",

doi = "10.1016/j.bmc.2007.07.037",

language = "英語",

volume = "15",

pages = "7098--7107",

journal = "Bioorganic and Medicinal Chemistry",

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TY - JOUR

T1 - Synthesis and pharmacological profile of serofendic acids A and B

AU - Terauchi, Taro

AU - Asai, Naoki

AU - Doko, Takashi

AU - Taguchi, Ryota

AU - Takenaka, Osamu

AU - Sakurai, Hideki

AU - Yonaga, Masahiro

AU - Kimura, Teiji

AU - Kajiwara, Akiharu

AU - Niidome, Tetsuhiro

AU - Kume, Toshiaki

AU - Akaike, Akinori

AU - Sugimoto, Hachiro

PY - 2007/11/15

Y1 - 2007/11/15

N2 - We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.

AB - We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.

KW - Atisane

KW - Glutamate

KW - Neurodegenerative disease

KW - Neuroprotective

KW - Neurotoxicity

KW - Serofendic acid

UR - http://www.scopus.com/inward/record.url?scp=34548838568&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2007.07.037

DO - 10.1016/j.bmc.2007.07.037

M3 - 学術論文

C2 - 17804246

AN - SCOPUS:34548838568

SN - 0968-0896

VL - 15

SP - 7098

EP - 7107

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 22

ER -

Synthesis and pharmacological profile of serofendic acids A and B

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