Synthesis and biological evaluation of 9Z-retinoic acid analogs having 2-substituted benzo[b]furan

Takashi Okitsu, Daisuke Nakazawa, Kimie Nakagawa, Toshio Okano, Akimori Wada*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

Palladium-catalyzed cross-coupling reactions of a 2-substituted 3-iodobenzo[b]furans and stannanyl ester afforded the stereoselective production of 9Z-retinoic acid ester analogs in good yields. These esters were then converted to the corresponding acids via basic hydrolysis in excellent yields, and their biological activities were evaluated. The analog changed the connected position of polyene side chain from 2-position to 3-position of benzo[b]furan decreased the biological activities dramatically, and the introduction of various substituents at 2-position afforded almost no effect on the activities.

本文言語英語
ページ(範囲)418-422
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
58
3
DOI
出版ステータス出版済み - 2010/03

ASJC Scopus 主題領域

  • 化学一般
  • 創薬

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