Synthesis and antitumor activity of the estrane analogue of OSW-1

Yuji Matsuya; Seiji Masuda; Noriko Ohsawa; Solange Adam; Théophile Tschamber; Jacques Eustache; Keiichi Kamoshita; Yoshikazu Sukenaga; Hideo Nemoto

doi:10.1002/ejoc.200400632

Synthesis and antitumor activity of the estrane analogue of OSW-1

Yuji Matsuya, Seiji Masuda, Noriko Ohsawa, Solange Adam, Théophile Tschamber, Jacques Eustache, Keiichi Kamoshita, Yoshikazu Sukenaga, Hideo Nemoto^*

^*この論文の責任著者

薬品製造学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

37 被引用数 (Scopus)

抄録

The estrane analogue of OSW-1, a potent antitumor natural saponin, was efficiently synthesized from estrone in 12 steps. The cytostatic activity of the compound against several human malignant tumor cells was examined and compared to those of the natural OSW-1 and cisplatin, the results suggesting that the modification of the steroidal component could be an effective approach in the search for new candidates of anticancer drugs.

本文言語	英語
ページ（範囲）	803-808
ページ数	6
ジャーナル	European Journal of Organic Chemistry
号	5
DOI	https://doi.org/10.1002/ejoc.200400632
出版ステータス	出版済み - 2005/02/25

ASJC Scopus 主題領域

物理化学および理論化学
有機化学

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10.1002/ejoc.200400632

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abstract = "The estrane analogue of OSW-1, a potent antitumor natural saponin, was efficiently synthesized from estrone in 12 steps. The cytostatic activity of the compound against several human malignant tumor cells was examined and compared to those of the natural OSW-1 and cisplatin, the results suggesting that the modification of the steroidal component could be an effective approach in the search for new candidates of anticancer drugs.",

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AU - Matsuya, Yuji

AU - Masuda, Seiji

AU - Ohsawa, Noriko

AU - Adam, Solange

AU - Tschamber, Théophile

AU - Eustache, Jacques

AU - Kamoshita, Keiichi

AU - Sukenaga, Yoshikazu

AU - Nemoto, Hideo

PY - 2005/2/25

Y1 - 2005/2/25

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AB - The estrane analogue of OSW-1, a potent antitumor natural saponin, was efficiently synthesized from estrone in 12 steps. The cytostatic activity of the compound against several human malignant tumor cells was examined and compared to those of the natural OSW-1 and cisplatin, the results suggesting that the modification of the steroidal component could be an effective approach in the search for new candidates of anticancer drugs.

KW - Antitumor agents

KW - Glycosilation

KW - Natural products

KW - Steroids

KW - Structure-activity relationships

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DO - 10.1002/ejoc.200400632

M3 - 学術論文

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SN - 1434-193X

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EP - 808

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

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ER -

Synthesis and antitumor activity of the estrane analogue of OSW-1

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