抄録
As one of our ongoing research project concerning development of a novel anti-influenza virus agent, dihydrofuran-fused perhydrophenanthrenes were derivatized by means of Williamson ether synthesis and Suzuki-Miyaura cross coupling reactions. Newly synthesized compounds were subjected to evaluation of anti-influenza virus activity using influenza A/Aichi/2/68 (H3N2 subtype) virus strain by a plaque titration method. These investigations revealed that incorporation of benzyl-type ether substituents was effective for exerting the inhibition activity of influenza virus proliferation.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1477-1481 |
ページ数 | 5 |
ジャーナル | Bioorganic and Medicinal Chemistry |
巻 | 18 |
号 | 4 |
DOI | |
出版ステータス | 出版済み - 2010/02/15 |
ASJC Scopus 主題領域
- 生化学
- 分子医療
- 分子生物学
- 薬科学
- 創薬
- 臨床生化学
- 有機化学