TY - JOUR
T1 - Sylvian fissure and medial temporal lobe structures in patients with schizophrenia
T2 - A magnetic resonance imaging study
AU - Aso, Mitsuo
AU - Suzuki, Michio
AU - Kawasaki, Yasuhiro
AU - Matsui, Mie
AU - Hagino, Hirofumi
AU - Kurokawa, Kenzo
AU - Seto, Hikaru
AU - Kurachi, Masayoshi
PY - 2001
Y1 - 2001
N2 - Volumes of the medial temporal lobe structures (i.e. the amygdala, hippocampus, and parahippocampal gyms), Sylvian fissure, and inferior horn of the lateral ventricle relative to the cerebral hemisphere were measured in 24 patients with schizophrenia and 23 normal controls using magnetic resonance imaging. The patients had significantly larger Sylvian fissures and inferior horns bilaterally than the controls. In the patients the right Sylvian fissure size showed a significant positive correlation with the duration of illness. Moreover, earlier onset of illness was significantly correlated with decreased volume of the left medial temporal lobe structures. These results replicate previous finding of inferior horn enlargement and suggest the significance of the Sylvian fissure and the medial temporal lobe structures in pathophysiology of schizophrenia.
AB - Volumes of the medial temporal lobe structures (i.e. the amygdala, hippocampus, and parahippocampal gyms), Sylvian fissure, and inferior horn of the lateral ventricle relative to the cerebral hemisphere were measured in 24 patients with schizophrenia and 23 normal controls using magnetic resonance imaging. The patients had significantly larger Sylvian fissures and inferior horns bilaterally than the controls. In the patients the right Sylvian fissure size showed a significant positive correlation with the duration of illness. Moreover, earlier onset of illness was significantly correlated with decreased volume of the left medial temporal lobe structures. These results replicate previous finding of inferior horn enlargement and suggest the significance of the Sylvian fissure and the medial temporal lobe structures in pathophysiology of schizophrenia.
KW - Age at the onset of illness
KW - Magnetic resonance imaging
KW - Medial temporal lobe structures
KW - Schizophrenia
KW - Sylvian fissure
UR - http://www.scopus.com/inward/record.url?scp=0035114333&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1819.2001.00784.x
DO - 10.1046/j.1440-1819.2001.00784.x
M3 - 学術論文
C2 - 11235858
AN - SCOPUS:0035114333
SN - 1323-1316
VL - 55
SP - 49
EP - 56
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
IS - 1
ER -
